Human memory strength is predicted by theta-frequency phase-locking of single neurons

@article{Rutishauser2010HumanMS,
  title={Human memory strength is predicted by theta-frequency phase-locking of single neurons},
  author={Ueli Rutishauser and Ian B. Ross and Adam N. Mamelak and Erin Margaret Schuman},
  journal={Nature},
  year={2010},
  volume={464},
  pages={903-907}
}
Learning from novel experiences is a major task of the central nervous system. In mammals, the medial temporal lobe is crucial for this rapid form of learning. The modification of synapses and neuronal circuits through plasticity is thought to underlie memory formation. The induction of synaptic plasticity is favoured by coordinated action-potential timing across populations of neurons. Such coordinated activity of neural populations can give rise to oscillations of different frequencies… Expand
Theta-phase dependent neuronal coding during sequence learning in human single neurons
TLDR
Spikes for three consecutive items in the sequence were phase-locked at distinct phases of the theta oscillation, suggesting that encoding stimulus information at distinct oscillatory phases may play a role in maintaining their sequential order in STM. Expand
Theta-Phase Dependent Neuronal Coding During Sequence Learning in Human Single Neurons
The ability to maintain a sequence of items in short-term memory (STM) is a fundamental cognitive function. In the rodent hippocampus, the representation of sequentially organized spatial locationsExpand
Theta-phase dependent neuronal coding during sequence learning in human single neurons
TLDR
Spikes for three consecutive items in the sequence were phase-locked at distinct phases of the theta oscillation, suggesting that encoding stimulus information at distinct oscillatory phases may play a role in maintaining sequential order in memory. Expand
Oscillations support co-firing of neurons in the service of human memory formation
TLDR
It is shown that theta and gamma oscillations in the medial-temporal-lobe synchronize neural firing during a memory task, and this results support the long-standing assumption that correlated neural firing supports human episodic memory formation. Expand
Single neurons throughout human memory regions phase-lock to hippocampal theta
TLDR
Results reveal that spike-time synchrony with hippocampal theta is a defining feature of cortico-hippocampal functional connections in humans and propose that theta phase-locking could mediate flexible inter-regional communication to shape the content and quality of episodic memories. Expand
Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories.
TLDR
Intracranial recordings taken as 56 neurosurgical patients studied and recalled lists of words revealed significant hippocampal PAC, with slow-theta activity modulating gamma band activity and phase preference during item encoding exhibited a biphasic pattern. Expand
Human hippocampal theta oscillations and the formation of episodic memories
TLDR
Recorded intracranial EEG data from 237 hippocampal electrodes in 33 neurosurgical patients as they performed an episodic memory task identified two distinct patterns of hippocampal oscillations, at ∼3 and ∼8 Hz, which are at the edges of the traditional 4–8 Hz human theta band. Expand
Main Text: Episodic memory relies on synaptic modifications transforming fleeting experiences into durable memory traces (1). The strengthening of synaptic connections between neurons that are active during the experience of an episode in turn critically depends on the temporal structure
Brain oscillations mediate efficient information transfer between neurons in animal models of memory. Theta and gamma oscillations in the medial temporal lobe are thought to establish short-latencyExpand
Rapid learning in visual cortical networks
TLDR
A novel mechanism of plasticity in visual cortex is revealed by which elevated low-frequency synchronization between individual neurons and local population activity accompanies the improvement in performance during learning. Expand
Theta Oscillations in the Human Medial Temporal Lobe during Real World Ambulatory Movement
TLDR
The results suggest that higher frequency theta indeed exists in humans during movement providing critical support for conserved neurobiological mechanisms for spatial navigation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Oscillatory brain states and learning: Impact of hippocampal theta-contingent training
TLDR
This finding provides important evidence from awake, behaving animals that supports recent advances in knowledge of brain sites and neurobiological mechanisms of learning and memory, specifically hippocampus and theta oscillations, and the biological plausibility of current models of hippocampal function. Expand
Brain Oscillations Control Timing of Single-Neuron Activity in Humans
TLDR
Recording from 1924 neurons indicates that theta and delta oscillations facilitate phase coding and that gamma oscillations help to decode combinations of simultaneously active neurons, providing support for the temporal-coding hypothesis in humans. Expand
Phase Locking of Single Neuron Activity to Theta Oscillations during Working Memory in Monkey Extrastriate Visual Cortex
TLDR
The results suggest that extrastriate visual cortex is involved in short-term maintenance of information and that theta oscillations provide a mechanism for structuring the recurrent interaction between neurons in different brain regions that underlie working memory. Expand
Human neocortical oscillations exhibit theta phase differences between encoding and retrieval
TLDR
It is shown that 6-13 Hz activity exhibits consistent phase across trials following experimental stimuli, and that this phase significantly differs between study and test stimuli, suggesting that oscillatory phase reflects the encoding-retrieval state of neural networks, supporting predictions of recent models of memory. Expand
Prefrontal Phase Locking to Hippocampal Theta Oscillations
TLDR
It is demonstrated that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm, and phase locking of prefrontal cells is predicted by the presence of significant correlations with hippocampal cells at positive delays up to 150 ms. Expand
A Proposed Function for Hippocampal Theta Rhythm: Separate Phases of Encoding and Retrieval Enhance Reversal of Prior Learning
TLDR
A hippocampal model shows how theta rhythm could be important for reversal in this task by providing separate functional phases during each 100-300 msec cycle, consistent with physiological data. Expand
Sleep-dependent theta oscillations in the human hippocampus and neocortex.
TLDR
The findings suggest that the generation mechanisms of theta oscillations in humans might have evolved from tonic to phasic in hippocampus during REM sleep and extended from hippocampus to cortex, where they appear in certain wakefulness-related states. Expand
Single-Trial Learning of Novel Stimuli by Individual Neurons of the Human Hippocampus-Amygdala Complex
TLDR
Two classes of neurons in the hippocampus and amygdala that exhibit single-trial learning are reported: novelty and familiarity detectors, which show a selective increase in firing for new and old stimuli, respectively. Expand
Sleep-Dependent θ Oscillations in the Human Hippocampus and Neocortex
Hippocampal θ waves recorded during rapid eye movement (REM) sleep are thought to play a critical role in memory consolidation in lower mammals, but previous attempts to detect similar θ oscillationsExpand
Cellular bases of hippocampal EEG in the behaving rat
TLDR
Movement-related RSA was correlated with a decrease in firing rate of pyramidal cells and an increase in the firing of both interneurons and granule cells, and Gradual phase-shifts of RSA were observed both in CA1 and the dentate gyrus. Expand
...
1
2
3
4
5
...