Human memory CTL response specific for influenza A virus is broad and multispecific.

@article{Gianfrani2000HumanMC,
  title={Human memory CTL response specific for influenza A virus is broad and multispecific.},
  author={Carmela Gianfrani and Carla Oseroff and John Sidney and Robert W. Chesnut and Alessandro Sette},
  journal={Human immunology},
  year={2000},
  volume={61 5},
  pages={438-52}
}
Class I restricted cytotoxic T-lymphocyte (CTL) responses are thought to be focused against few immunodominant epitopes. In humans, an often quoted example of such narrow focus is the influenza A (FLU) matrix 58-66 specific memory CTL activity, detectable in HLA-A2 individuals as a result of natural infection. Herein, we analyzed the repertoire of memory, FLU-specific CTLs in A2 and A11 positive individuals. Eighteen A2.1 binding peptides, derived from the FLU-Puerto Rico/8/34 (PR8) isolate… CONTINUE READING
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