Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha.

@article{Dennis1998HumanMM,
  title={Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha.},
  author={John U. Dennis and Nicholas M. Dean and Christopher F Bennett and James W. Griffith and Cathy Lang and Danny R Welch},
  journal={Cancer letters},
  year={1998},
  volume={128 1},
  pages={65-70}
}
To determine whether alteration of PKC alpha expression would affect the metastatic potential of human melanoma cells, replicate cultures of C8161 cells were treated in vitro with a phosphorothioate antisense oligodeoxynucleotide (ODN) that specifically inhibits PKC alpha expression (ISIS-3521). Control C8161 cultures were treated with a scrambled sequence… CONTINUE READING