Human melanoma cells sensitive to deoxyadenosine and deoxyinosine.

  title={Human melanoma cells sensitive to deoxyadenosine and deoxyinosine.},
  author={Peter G Parsons and Ian P. Hayward},
  journal={Biochemical pharmacology},
  volume={35 4},
In an in vitro study conducted without the use of adenosine/deoxyadenosine deaminase inhibitors, two human melanoma cell lines, MM96L and MM127, were found to be highly sensitive to killing by continuous treatment with deoxyadenosine (dAdo) (D37 47 microM and 68 microM respectively) compared with fibroblasts (D37 440 microM), Hela cells (D37 1.1 mM) and other melanoma cell lines (D37 0.8 to 2.5 mM). Cross-sensitivity was found to deoxyinosine (dIno) and in part to adenosine but not to related… CONTINUE READING
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