Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.

@article{Zhang2006HumanMC,
  title={Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.},
  author={Xu Dong Zhang and Jing Jing Wu and Susan K.H. Gillespie and Jodie M Borrow and Peter Hersey},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 4},
  pages={1355-64}
}
PURPOSE Heterogeneous sensitivity of melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis may lead to outgrowth of TRAIL-resistant cells and limit successful treatment by TRAIL. The present study aims to better understand the biological characteristics of melanoma cells resistant to TRAIL-induced apoptosis. EXPERIMENTAL DESIGN We generated TRAIL-resistant melanoma cells by prolonged exposure to TRAIL and characterized the cells in terms of their… CONTINUE READING

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Antitumor activity of 3 - ingenyl angelate : plasma membrane and mitochondrial disruption and necrotic cell death

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