Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97.

@article{Casellas1982HumanMC,
  title={Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97.},
  author={Pierre Casellas and Joseph P. Brown and Olivier Gros and Piet Gros and Ingegerd Hellstr{\"o}m and Franz K. Jansen and Philippe Poncelet and Romeo Roncucci and Hubert Vidal and Karl Erik Hellstr{\"o}m},
  journal={International journal of cancer},
  year={1982},
  volume={30 4},
  pages={437-43}
}
Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 molecules of p97 were not killed. The presence of 10 mM ammonium chloride significantly increased the efficiency of the immunotoxin, tumor cells expressing high levels of p97 being… CONTINUE READING

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