Human melanogenesis is stimulated by diacylglycerol.

  title={Human melanogenesis is stimulated by diacylglycerol.},
  author={Pierce Gordon and Barbara A. Gilchrest},
  journal={The Journal of investigative dermatology},
  volume={93 5},
The intracellular signal pathways that mediate pigmentation in human skin are unknown. We now report that a diacylglycerol (DAG) analogue 1-oleoyl-2-acetyl-glycerol (OAG) 25-100 microns strikingly increased the melanin content of cultured human melanocytes in a dose dependent manner without altering growth rate. The pigment increase occurred within 24 h, was accompanied by increased incorporation of the melanin precursor L-3,4-dihydroxyphenyl alanine (DOPA), required new protein synthesis, and… CONTINUE READING

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