Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes.

@article{Sbardella2012HumanMM,
  title={Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes.},
  author={Diego Sbardella and Giovanni Francesco Fasciglione and Magda Gioia and Chiara Ciaccio and Grazia R Tundo and Stefano Marini and Massimo Coletta},
  journal={Molecular aspects of medicine},
  year={2012},
  volume={33 2},
  pages={119-208}
}
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn(2+) atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to… CONTINUE READING