Human mast cells stimulate activated T cells: implications for multiple sclerosis.

@article{Theoharides2008HumanMC,
  title={Human mast cells stimulate activated T cells: implications for multiple sclerosis.},
  author={Theoharis C Theoharides and Duraisamy Kempuraj and Taxiarchis Kourelis and Akrivi Manola},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1144},
  pages={74-82}
}
Multiple sclerosis is an autoimmune demyelinating disease of the central nervous system mainly mediated by Th1 and/or Th17 cells, which cross the blood-brain barrier. Recent evidence indicates that Th2 cells and mast cells, typically associated with allergic reactions, are also involved. Brain mast cells are critically located perivascularly and secrete numerous proinflammatory and vasoactive molecules that can disrupt the blood-brain barrier, a finding that precedes clinical or pathologic… CONTINUE READING
21 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…