Human mast cells and basophils in HIV-1 infection.

  title={Human mast cells and basophils in HIV-1 infection.},
  author={Gianni Marone and Giovanni Florio and Angelica Petraroli and Massimo Triggiani and Amato de Paulis},
  journal={Trends in immunology},
  volume={22 5},
Mast cells and basophils (FcvarepsilonRI(+) cells) are classically involved in allergic disorders. HIV-1 glycoprotein gp120 acts as a viral superantigen by interacting with the heavy chain, variable 3 (V(H)3) region of IgE to induce cytokine release from FcvarepsilonRI(+) cells. The chemokine receptors CCR3 and CXCR4, co-receptors for HIV-1, are expressed by FcvarepsilonRI(+) cells. Via its interaction with CCR3, HIV-1 transactivation (Tat) protein is a potent chemoattractant for FcvarepsilonRI… CONTINUE READING

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