Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system.

@article{Schemann2005HumanMC,
  title={Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system.},
  author={Michael Schemann and Klaus C. Michel and Michał Ceregrzyn and Florian Zeller and Stefan Seidl and Stephan C. Bischoff},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2005},
  volume={17 2},
  pages={281-9}
}
Neuroimmune interactions are an integral part of gut physiology and involved in the pathogenesis of inflammatory and functional bowel disorders. Mast cells and their mediators are important conveyors in the communication from the innate enteric immune system to the enteric nervous system (ENS). However, it is not known whether a mediator cocktail released from activated human mast cells affects neural activity in the ENS. We used the Multi-Site Optical Recording Technique to image single cell… CONTINUE READING
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