Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.

@article{LaBarge2009HumanMP,
  title={Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments.},
  author={Mark A LaBarge and Celeste M. Nelson and Ren{\'e} Villadsen and Agla Jael Rubner Fridriksdottir and Jason R. Ruth and Martha R. Stampfer and Ole William Petersen and Mina J. Bissell},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2009},
  volume={1 1},
  pages={
          70-9
        }
}
In adult tissues, multi-potent progenitor cells are some of the most primitive members of the developmental hierarchies that maintain homeostasis. That progenitors and their more mature progeny share identical genomes, suggests that fate decisions are directed by interactions with extrinsic soluble factors, ECM, and other cells, as well as physical properties of the ECM. To understand regulation of fate decisions, therefore, would require a means of understanding carefully choreographed… CONTINUE READING
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