Human male infertility caused by mutations in the CATSPER1 channel protein.

  title={Human male infertility caused by mutations in the CATSPER1 channel protein.},
  author={M. Avenarius and Michael S. Hildebrand and Yuzhou Zhang and Nicole C. Meyer and Luke Lanning Smith and Kimia Kahrizi and Hossein Najmabadi and Richard J. H. Smith},
  journal={American journal of human genetics},
  volume={84 4},
Male infertility, a common barrier that prevents successful conception, is a reproductive difficulty affecting 15% of couples. Heritable forms of nonsyndromic male infertility can arise from single-gene defects as well as chromosomal abnormalities. Although no CATSPER gene has been identified as causative for human male infertility, male mice deficient for members of the CatSper gene family are infertile. In this study, we used routine semen analysis to identify two consanguineous Iranian… CONTINUE READING
62 Citations
16 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 62 extracted citations


Publications referenced by this paper.
Showing 1-10 of 16 references

A sperm ion channel erican

  • D. Ren, B. Navarro, +5 authors D. E. Clapham
  • Journal of Human Genetics
  • 2001
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…