Human major histocompatibility complex contains several leukemia susceptibility genes.

@article{Dorak1994HumanMH,
  title={Human major histocompatibility complex contains several leukemia susceptibility genes.},
  author={Mehmet Tevfik Dorak and Elizabeth A Chalmers and Dairena Gaffney and Duncan W Wilson and Ian A. Galbraith and N. George Henderson and Mark Worwood and Kenneth Ian Mills and Alan Kenneth Burnett},
  journal={Leukemia & lymphoma},
  year={1994},
  volume={12 3-4},
  pages={
          211-22
        }
}
In mice, homozygosity for the Mhc haplotype H-2k is associated with increased susceptibility to spontaneous and virus-induced leukemia, lymphoma and other neoplasms in the predisposed host. The influence of the Mhc on malignant development in these models is to shorten the latency after virus inoculation. Here, we present evidence that a similar phenomenon results in early-onset of human leukemia. A molecular analysis of the MHC in 112 CML patients showed that those who developed the disease… CONTINUE READING

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