Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens.

@article{Andreesen1986HumanMM,
  title={Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens.},
  author={Reinhard Andreesen and Klaus J. Bross and Jurgen Osterholz and Frank Emmrich},
  journal={Blood},
  year={1986},
  volume={67 5},
  pages={1257-64}
}
We have analyzed the expression of late differentiation antigens during terminal in vitro maturation of human macrophages (M phi) from blood monocytes (MO) in comparison to their distribution among mature M phi residing in various tissue sites. By immunizing mice with M phi derived from blood MO by culture on hydrophobic Teflon foils, monoclonal antibodies (mAbs) were developed (MAX.1, MAX.2, MAX.3, MAX.11) that reacted with lineage-restricted differentiation antigens. These antigens were… CONTINUE READING

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