Human lymphocytes shed a soluble form of CD21 (the C3dg/Epstein‐Barr virus receptor, CR2) that binds iC3b and CD23

@article{FrmeauxBacchi1996HumanLS,
  title={Human lymphocytes shed a soluble form of CD21 (the C3dg/Epstein‐Barr virus receptor, CR2) that binds iC3b and CD23},
  author={V. Fr{\'e}meaux-Bacchi and I. Bernard and F. Maillet and J. Mani and M. Fontaine and J. Bonnefoy and M. Kazatchkine and E. Fischer},
  journal={European Journal of Immunology},
  year={1996},
  volume={26}
}
  • V. Frémeaux-Bacchi, I. Bernard, +5 authors E. Fischer
  • Published 1996
  • Biology, Medicine
  • European Journal of Immunology
  • We report on a soluble (s) form of CD21 (the C3dg/Epstein‐Barr virus receptor, CR2) that is spontaneously released by B and T lymphocytes. Immunoprecipitation with anti‐CD21 mAb of culture supernatants of surface and biosynthetically labeled B and T cell lines revealed a single band with an apparent molecular mass of 135 kDa. The molecule exhibited a molecular mass 10 kDa lower than that of membrane CD21. The release of soluble CD21 (sCD21) was time dependent and correlated with a parallel… CONTINUE READING
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