Human lymphocyte apoptosis after exposure to influenza A virus.

@article{Nichols2001HumanLA,
  title={Human lymphocyte apoptosis after exposure to influenza A virus.},
  author={Joan E Nichols and Jean A Niles and Norbert J. Roberts},
  journal={Journal of virology},
  year={2001},
  volume={75 13},
  pages={5921-9}
}
Infection of humans with influenza A virus (IAV) results in a severe transient leukopenia. The goal of these studies was to analyze possible mechanisms behind this IAV-induced leukopenia with emphasis on the potential induction of apoptosis of lymphocytes by the virus. Analysis of lymphocyte subpopulations after exposure to IAV showed that a portion of CD3(+), CD4(+), CD8(+), and CD19(+) lymphocytes became apoptotic (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling… CONTINUE READING

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