Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

@article{Means2005HumanLA,
  title={Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.},
  author={Terry K. Means and Eicke Latz and Fumitaka Hayashi and Mandakolathur R. Murali and Douglas T Golenbock and Andrew D Luster},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 2},
  pages={407-17}
}
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs (PDCs) to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcgammaRIIa (CD32). SLE-ICs transiently colocalized to a… CONTINUE READING
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