Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule

@article{Chen1991HumanLT,
  title={Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule},
  author={Felix A. Chen and Elizabeth A. Repasky and Richard B Bankert},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={173},
  pages={1111 - 1119}
}
A single chain glycoprotein with an estimated molecular mass of 160 kD (gp160) was previously identified as a human lung tumor-associated antigen. This tumor marker is shown here to be associated noncovalently with a second 130-kD protein. Sequential immunoprecipitation studies of surface iodinated lung tumor cell lysates reveal that this heterodimeric complex is indistinguishable serologically and structurally from the integrin VLA-2, found originally on activated T lymphocytes and platelets… CONTINUE READING

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