Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection.

@article{Arcos2011HumanLH,
  title={Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection.},
  author={Jes{\'u}s Arcos and Smitha J. Sasindran and Nagatoshi Fujiwara and Joanne H. Turner and Larry S. Schlesinger and Jordi B Torrelles},
  journal={Journal of immunology},
  year={2011},
  volume={187 1},
  pages={372-81}
}
Pulmonary surfactant contains homeostatic and antimicrobial hydrolases. When Mycobacterium tuberculosis is initially deposited in the terminal bronchioles and alveoli, as well as following release from lysed macrophages, bacilli are in intimate contact with these lung surfactant hydrolases. We identified and measured several hydrolases in human alveolar lining fluid and lung tissue that, at their physiological concentrations, dramatically modified the M. tuberculosis cell envelope. Independent… CONTINUE READING
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