Human lung carcinomas express Fas ligand.

@article{Niehans1997HumanLC,
  title={Human lung carcinomas express Fas ligand.},
  author={Gloria A. Niehans and Thomas Levin Brunner and Sandra P. Frizelle and Joyce C Liston and Christopher Salerno and Darin J. Knapp and Douglas R Green and Robert Arthur Kratzke},
  journal={Cancer research},
  year={1997},
  volume={57 6},
  pages={1007-12}
}
To reach a clinically detectable size, neoplasms must be able to suppress or evade a host immune response. Activated T cells may enter apoptosis in the presence of Fas ligand (FasL) (1), and tissue expression of FasL has been shown to contribute to immune privilege in the eye and testis (2, 3). We have demonstrated that all human lung carcinoma cell lines tested (16 of 16) express a Mr 38,000 protein consistent with FasL by immunoblotting, whereas the majority of resected tumors (23 of 28) show… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 59 references

Faa ligand in human serum

  • M. Tanaka, T. Suds, +10 authors S. Nagata
  • Nat . Med .
  • 1996

Lymphocyte apoptosis induced by CD 95 ( APOl / Fas ) ligandexpressing tumor cells†” amechanism of immune evasion ?

  • S. Strand, W. J. Hofmann, +7 authors P. R. Galle
  • Nat . Med .
  • 1996

Lymphocyte apoptosis induced by CD95 (APO-l/Fas) ligand-expressing tumor cells—amechanism of immune evasion? Nat.Med.,2: 1361—1366

  • S. Strand, W. J. Hofmann, +7 authors P. R. Galle
  • 1996

Melanoma cell expression of Fas(Apo-l/CD95) ligand: implications for tumor im mune escape

  • M. Hahne, D. Rimoldi, +10 authors J. Tschopp
  • Science (Washington DC),
  • 1996

Autocrine T-cell suicide mediated by APO-l/(Fas/CD95)

  • J. Dhein, H. Walczak, C. Btumler, Debatin, K-M, P. H. Krammer
  • Nature (Lond.),
  • 1995

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