Human lung cancer cell lines exhibit resistance to retinoic acid treatment.

@article{Geradts1993HumanLC,
  title={Human lung cancer cell lines exhibit resistance to retinoic acid treatment.},
  author={Joseph Geradts and Jyh Yih Chen and Elizabeth. Russell and James R. Yankaskas and Luis David Gonz{\'a}les Nieves and John D. Minna},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1993},
  volume={4 10},
  pages={
          799-809
        }
}
Retinoic acid (RA) and nuclear retinoic acid receptors (RARs) have been implicated in a variety of human malignancies including lung cancer, and RA has been proposed as a chemopreventive agent for bronchogenic carcinoma. Normal human tracheobronchial epithelial cells show dramatic induction of RAR-beta mRNA and significant growth inhibition after RA treatment. In contrast, 17 of 22 small cell lung cancer (SCLC) and 9 of 15 non-SCLC lines treated with 1 microM RA showed no significant growth… CONTINUE READING

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