Human lung cancer and p53: the interplay between mutagenesis and selection.

@article{Rodin2000HumanLC,
  title={Human lung cancer and p53: the interplay between mutagenesis and selection.},
  author={Sergei N. Rodin and Andrei S. Rodin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 22},
  pages={12244-9}
}
It is an almost consensus opinion that the major carcinogenic risk of tobacco smoke is in its direct mutagenic action on DNA of cancer-related genes. The key data supposedly linking smoke-induced mutations to lung cancer were obtained from the adduct spectrum of the p53 tumor suppressor gene. Results of our analysis of p53 mutations compiled from the International Agency for Research on Cancer p53 database (April 1999 update) and from the literature point to a different causative link. Our new… CONTINUE READING

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