Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity.

@article{Minassian2007HumanLC,
  title={Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity.},
  author={Karen Minassian and Ilse Persy and Frank Rattay and M. M. Pinter and Helmut Kern and Milan R. Dimitrijevic},
  journal={Human movement science},
  year={2007},
  volume={26 2},
  pages={275-95}
}
We have demonstrated that non-patterned electrical stimulation of the lumbar cord can induce stepping-like activity in the lower limbs of complete spinal cord injured individuals. This result suggested the existence of a human lumbar locomotor pattern generator, which can convert a tonic input to a rhythmic motor output. We have studied the human lumbar cord in isolation from supraspinal input but under extrinsic tonic input delivered by spinal cord stimulation. Large-diameter afferents within… CONTINUE READING
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