Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors.

@article{Ng2012HumanLN,
  title={Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors.},
  author={Shi-Yan Ng and Rory Johnson and Lawrence Walter Stanton},
  journal={The EMBO journal},
  year={2012},
  volume={31 3},
  pages={522-33}
}
Long non-coding RNAs (lncRNAs) are a numerous class of newly discovered genes in the human genome, which have been proposed to be key regulators of biological processes, including stem cell pluripotency and neurogenesis. However, at present very little functional characterization of lncRNAs in human differentiation has been carried out. In the present study, we address this using human embryonic stem cells (hESCs) as a paradigm for pluripotency and neuronal differentiation. With a newly… CONTINUE READING
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