Human liver phenol sulfotransferase: assay conditions, biochemical properties and partial purification of isozymes of the thermostable form.

@article{Campbell1987HumanLP,
  title={Human liver phenol sulfotransferase: assay conditions, biochemical properties and partial purification of isozymes of the thermostable form.},
  author={Norman Campbell and Jeanne van Loon and Richard M. Weinshilboum},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 9},
  pages={1435-46}
}
Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic and catechol drugs and neurotransmitters. Human platelets and brain contain at least two forms of PST. One form is relatively thermolabile (TL) and catalyzes the sulfate conjugation of monoamines such as dopamine. The other is thermostable (TS) and catalyzes the sulfation of "simple" phenols such as phenol and p-nitrophenol. We found that homogenates of human liver also contain two forms of PST that are similar to brain… CONTINUE READING
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