Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.

@article{Carpenter1992HumanLL,
  title={Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.},
  author={K. Carpenter and R. Pollitt and B. Middleton},
  journal={Biochemical and biophysical research communications},
  year={1992},
  volume={183 2},
  pages={
          443-8
        }
}
  • K. Carpenter, R. Pollitt, B. Middleton
  • Published 1992
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • We have purified to homogeneity the long-chain specific 3-hydroxyacyl-CoA dehydrogenase from mitochondrial membranes of human infant liver. The enzyme is composed of non-identical subunits of 71 kDa and 47 kDa within a native structure of 230 kDa. The pure enzyme is active with 3-ketohexanoyl-CoA and gives maximum activity with 3-ketoacyl-CoA substrates of C10 to C16 acyl-chain length but is inactive with acetoacetyl-CoA. In addition to 3-hydroxyacyl-CoA dehydrogenase activity, the enzyme… CONTINUE READING
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