Human liver class III alcohol and glutathione dependent formaldehyde dehydrogenase are the same enzyme.

@article{Holmquist1991HumanLC,
  title={Human liver class III alcohol and glutathione dependent formaldehyde dehydrogenase are the same enzyme.},
  author={Barton Holmquist and Bert L. Vallee},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={178 3},
  pages={1371-7}
}
Human liver class III alcohol dehydrogenase (chi chi-ADH) and glutathione dependent formaldehyde dehydrogenase are the same enzyme. The enzyme, chi chi-ADH, exhibits a kcat of 200 min-1 and a km of 4 microM for the oxidation of formaldehyde, but only in the presence of GSH. In the absence of GSH the enzyme is essentially inactive toward formaldehyde but very active toward long chain alcohols. Thus, as in the rat (Koivusalo, M., Baumann, M., and Uotila, L. (1989) FEBS Letters 257, 105-109), the… CONTINUE READING
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