Human leumorphin is a potent, kappa opioid receptor agonist

@article{Suda1984HumanLI,
  title={Human leumorphin is a potent, kappa opioid receptor agonist},
  author={Mitsuaki Suda and Kazuwa Nakao and Takaaki Yoshimasa and Makoto Sakamoto and Narito Morii and Yoshio Ikeda and Chizuko Yanaihara and Noboru Yanaihara and Shosaku Numa and Hiroo Imura},
  journal={Neuroscience Letters},
  year={1984},
  volume={50},
  pages={49-52}
}
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7 Citations

7 Citations

Citation Type

Citation Type

Leumorphin in human brain
Characterization of Opioid Receptors Modulating Neurogenic Contractions of Circular Muscle from Porcine Ileum and Evidence That δ- and κ-Opioid Receptors Are Coexpressed in Myenteric Neurons
TLDR
The results suggest that myEnteric δ- and κ-opioid receptors mediate the antitransit effects of opioids in the porcine small intestine and may be functionally coupled in a subpopulation of myenteric neurons.
Changes in the immunoreactivities of an opioid peptide leumorphin in the hypothalamus and anterior pituitary during the estrous cycle of the rat and their relation to sexual behavior
Distribution of human leumorphin-like immunoreactivity in the monkey spinal cord revealed by immunocytochemistry
Prodynorphin peptide distribution in the forebrain of the syrian hamster and rat: A comparative study with antisera against dynorphin A, dynorphin B, and the C‐terminus of the prodynorphin precursor molecule
The neuroanatomical distribution of the prodynorphin precursor molecule in the forebrain of the male Syrian hamster (Mesocricetus auratus) has been studied with a novel antiserum directed against the…
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
TLDR
This chapter discusses the development of Salvinorin A, a novel Opioid Synthesis Procedure, and some of the techniques used to develop it.

References

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A novel opioid peptide, leumorphin, acts as an agonist at the κ opiate receptor
Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B.
Synthesis of porcine leumorphin and some of its biological activities
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.
TLDR
The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay.
Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone).
TLDR
It seemed of interest, therefore, to examine the kinetics of these drugs and for this purpose the following parameters were chosen: the concentration causing 50% inhibition of the contraction of the longitudinal muscle (ID50), to characterize agonist activity; the equilibrium constant and the recovery rate constant, to characterize antagonist activity.
Rimorphin (dynorphin B) exists together with alpha-neo-endorphin and dynorphin (dynorphin A) in human hypothalamus.
Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
The primary structure of a precursor protein that contains β-neo-endorphin, dynorphin and a third leucine-enkephalin sequence with a carboxyl extension has been deduced from the nucleotide sequence…
Isolation and structural organization of the human preproenkephalin gene
TLDR
The general organization of the preproenkephalin gene is strikingly similar to that of the gene encoding the common precursor of corticotropin and β-lipotropin (β-LPH)7–9 (alternatively designated preproopiomelanocortin), another multi-hormone precursor.
Rabbit vas deferens: A specific bioassay for opioid κ-receptor agonists