Human leumorphin is a potent, kappa opioid receptor agonist

@article{Suda1984HumanLI,
  title={Human leumorphin is a potent, kappa opioid receptor agonist},
  author={Mitsuaki Suda and Kazuwa Nakao and Takaaki Yoshimasa and Makoto Sakamoto and Narito Morii and Yoshio Ikeda and Chizuko Yanaihara and Noboru Yanaihara and Shosaku Numa and Hiroo Imura},
  journal={Neuroscience Letters},
  year={1984},
  volume={50},
  pages={49-52}
}
7 Citations
Leumorphin in human brain
Characterization of Opioid Receptors Modulating Neurogenic Contractions of Circular Muscle from Porcine Ileum and Evidence That δ- and κ-Opioid Receptors Are Coexpressed in Myenteric Neurons
TLDR
The results suggest that myEnteric δ- and κ-opioid receptors mediate the antitransit effects of opioids in the porcine small intestine and may be functionally coupled in a subpopulation of myenteric neurons.
Prodynorphin peptide distribution in the forebrain of the syrian hamster and rat: A comparative study with antisera against dynorphin A, dynorphin B, and the C‐terminus of the prodynorphin precursor molecule
The neuroanatomical distribution of the prodynorphin precursor molecule in the forebrain of the male Syrian hamster (Mesocricetus auratus) has been studied with a novel antiserum directed against the
Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
TLDR
This chapter discusses the development of Salvinorin A, a novel Opioid Synthesis Procedure, and some of the techniques used to develop it.

References

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Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B.
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TLDR
The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay.
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TLDR
It seemed of interest, therefore, to examine the kinetics of these drugs and for this purpose the following parameters were chosen: the concentration causing 50% inhibition of the contraction of the longitudinal muscle (ID50), to characterize agonist activity; the equilibrium constant and the recovery rate constant, to characterize antagonist activity.
Rimorphin (dynorphin B) exists together with alpha-neo-endorphin and dynorphin (dynorphin A) in human hypothalamus.
Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
The primary structure of a precursor protein that contains β-neo-endorphin, dynorphin and a third leucine-enkephalin sequence with a carboxyl extension has been deduced from the nucleotide sequence
Isolation and structural organization of the human preproenkephalin gene
TLDR
The general organization of the preproenkephalin gene is strikingly similar to that of the gene encoding the common precursor of corticotropin and β-lipotropin (β-LPH)7–9 (alternatively designated preproopiomelanocortin), another multi-hormone precursor.