Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.

@article{Kikuta1998HumanLB,
  title={Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.},
  author={Yasushi Kikuta and Mamoru Kato and Yoriaki Yamashita and Yasuhiro Miyauchi and Kimiko Tanaka and Nobuo Kamada and M. Kusunose},
  journal={DNA and cell biology},
  year={1998},
  volume={17 3},
  pages={
          221-30
        }
}
Leukotriene B4 (LTB4) omega-hydroxylase catalyzes the conversion of LTB4 into a biologically less active product, 20-hydroxy-LTB4. In a preceding paper (Kikuta et al., 1993), we showed human polymorphonuclear leukocyte (PMN) LTB4 omega-hydroxylase to be a novel form of cytochrome P450, designated CYP4F3, on the basis of its cDNA cloning and expression in yeast cells. Here, we have isolated the gene encoding CYP4F3 and determined its genomic organization and chromosomal localization. The CYP4F3… CONTINUE READING

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