Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells.

@article{Alla2008HumanLE,
  title={Human leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells.},
  author={Vijay Alla and Anubha Kashyap and Sebastian Paul Gregor and Matthias Theobald and Hans Heid and Peter Robert Galle and Dennis Strand and Susanne Strand},
  journal={Cancer letters},
  year={2008},
  volume={268 2},
  pages={331-9}
}
Matrix metalloproteinase-7 (MMP-7/Matrilysin) is a component of the tumor microenvironment associated with malignant progression. Its expression in tumors protects tumor cells from CD95-mediated apoptosis and the cytotoxic activity of tumor specific CD8(+) T cells. In the present study, we show that human leukocyte elastase (HLE) secreted by polymorphonuclear leukocytes cleaves MMP-7 resulting in loss of enzymatic activity. The anti-apoptotic effect of MMP-7 is reduced in the presence of HLE… CONTINUE READING

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