Human leukocyte antigen epitope antigenicity and immunogenicity

@article{Duquesnoy2014HumanLA,
  title={Human leukocyte antigen epitope antigenicity and immunogenicity},
  author={Ren{\'e} J. Duquesnoy},
  journal={Current Opinion in Organ Transplantation},
  year={2014},
  volume={19},
  pages={428–435}
}
  • R. Duquesnoy
  • Published 1 August 2014
  • Biology, Medicine
  • Current Opinion in Organ Transplantation
Purpose of reviewHuman leukocyte antigen (HLA) antibodies are now recognized as being specific for epitopes which can be defined structurally with amino acid differences between HLA alleles. This article addresses two general perspectives of HLA epitopes namely antigenicity, that is their reactivity with antibody and immunogenicity, that is their ability of eliciting an antibody response. Recent findingsSingle-antigen bead assays have shown that HLA antibodies recognize epitopes that are… 
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53 Citations
Highly Influential Citations
1
Background Citations
24
Methods Citations
4
Results Citations
2

53 Citations

Usefulness of the Nonself-Self Algorithm of HLA Epitope Immunogenicity in the Specificity Analysis of Monospecific Antibodies Induced during Pregnancy

A new antibody analysis approach is developed that utilizes the nonself–self algorithm of HLA epitope immunogenicity, based on the concept that HLA antibodies originate from B-cells with immunoglobulin receptors to self-HLA epitopes on one given allele and which can be activated by epitopes defined by a few nonself residue differences.

Antibody-defined epitopes on HLA-DQ alleles reacting with antibodies induced during pregnancy and the design of a DQ eplet map.

Auto- and allo-epitopes in DQ alloreactive antibodies

  • A. Tambur
  • Biology, Medicine
    Current opinion in organ transplantation
  • 2016
Evidence is provided to refute the use of ‘self-epitopes’ as an immunologically feasible terminology by delineating the historic events leading to today's misconceptions and supporting the need for a change in current practices on analyzing HLA-DQ antibodies.

Usefulness of the ElliPro epitope predictor program in defining the repertoire of HLA-ABC eplets.

Defining the immunogenicity and antigenicity of HLA epitopes is crucial for optimal epitope matching in clinical renal transplantation

The latest insights on HLA epitopes are described with a special focus on the definition of immunogenicity and antigenicity of Hla epitopes and the use of this knowledge to prevent HLA antibody formation and to select the optimal donor for sensitised transplant candidates will be discussed.

Epitope matching in kidney transplantation: recent advances and current limitations.

Epitope matching likely represents a valid progression in understanding donor-recipient HLA compatibility, but more clinical data and a better understanding about differences in methods to determine epitope compatibility are required before the approach can be widely applied in clinical practice.

From HLA typing to anti-HLA antibody detection and beyond: The road ahead.

Reflections on HLA Epitope-Based Matching for Transplantation

Personal reflections about epitopes including a historical perspective of HLA typing at the antigen and allele levels, the repertoires of antibody-verified HLA epitopes, the use of HLAMatchmaker in determining the specificities of antibodies tested in different assays, and, finally, possible strategies to control HLA antibody responses are described.

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation.

This work sought to develop a complementary method using a different technology to detect and characterize anti-donor HLA antibodies on a personalized basis, and was able to detect anti-HLA signals with the resolution that also allowed us to pinpoint the immune epitopes involved.

Should epitope-based HLA compatibility be used in the kidney allocation system?

...

References

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