Human leukocyte antigen epitope antigenicity and immunogenicity

  title={Human leukocyte antigen epitope antigenicity and immunogenicity},
  author={Ren{\'e} J. Duquesnoy},
  journal={Current Opinion in Organ Transplantation},
  • R. Duquesnoy
  • Published 1 August 2014
  • Biology, Medicine
  • Current Opinion in Organ Transplantation
Purpose of reviewHuman leukocyte antigen (HLA) antibodies are now recognized as being specific for epitopes which can be defined structurally with amino acid differences between HLA alleles. This article addresses two general perspectives of HLA epitopes namely antigenicity, that is their reactivity with antibody and immunogenicity, that is their ability of eliciting an antibody response. Recent findingsSingle-antigen bead assays have shown that HLA antibodies recognize epitopes that are… 

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