Human leukocyte antigen class I expression on squamous cell carcinoma cells regulates natural killer cell activity.

@article{Lutz1999HumanLA,
  title={Human leukocyte antigen class I expression on squamous cell carcinoma cells regulates natural killer cell activity.},
  author={Charles T. Lutz and Zoya B Kurago},
  journal={Cancer research},
  year={1999},
  volume={59 22},
  pages={5793-9}
}
Human leukocyte antigen (HLA) class I molecules on hematopoietic cancers and melanomas inhibit attack by natural killer lymphocytes, but previous studies have not consistently demonstrated that carcinoma cells are protected by HLA class I expression. We investigated whether HLA class I molecules protect oral and pharyngeal squamous cell carcinoma cells from natural killer lymphocyte attack. Squamous cell carcinoma cell lines expressed varying levels of HLA class I, which correlated inversely… CONTINUE READING
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