Human leukocyte antigen-G protein expression is an unfavorable prognostic predictor of hepatocellular carcinoma following curative resection.

@article{Cai2009HumanLA,
  title={Human leukocyte antigen-G protein expression is an unfavorable prognostic predictor of hepatocellular carcinoma following curative resection.},
  author={Ming-yan Cai and Yongfeng Xu and Shuang-jian Qiu and Min-jie Ju and Qiang Gao and Yi-wei Li and Boheng Zhang and Jian Zhou and Jia Fan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 14},
  pages={4686-93}
}
PURPOSE Human leukocyte antigen-G (HLA-G) is a tumor-associated immunosuppressive molecule involved in tumor escape mechanisms. The aim of this study is to elucidate its prognostic significance in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN Immunohistochemical staining of HLA-G expression as well as tumor-infiltrating FoxP3+ regulatory (Tregs) and CD8+ cytotoxic T cells was carried out on tissue microarrays containing 173 HCC tissue specimens. Membrane-bound HLA-G1 protein expression… CONTINUE READING

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