Human leukocyte antigen DQ2.2 and celiac disease.

@article{Mubarak2013HumanLA,
  title={Human leukocyte antigen DQ2.2 and celiac disease.},
  author={Amani Mubarak and Eric Spierings and Victorien M. Wolters and Ingrid M W van Hoogstraten and C. M. Frank Kneepkens and Roderick Henk Johan Houwen},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2013},
  volume={56 4},
  pages={
          428-30
        }
}
Patients with celiac disease (CD) lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA1*05:01, DQB1*02:01) or trans (DQA1*05:05, DQB1*02:02) configuration and HLA-DQ8 (DQA1*03:01, DQB1*03:02) are considered to be rare. Therefore, absence of these genotypes is commonly used to exclude the diagnosis of CD. To investigate whether this approach is justified, the HLA-distribution in 155 children with CD was studied. A total of 139 (89.7%) patients carried HLA-DQ2.5. Of the remaining patients… CONTINUE READING
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