Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity.

@article{Rossman2002HumanLA,
  title={Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity.},
  author={Milton D. Rossman and Jose Stubbs and Chung Wha Lee and Elias G. Argyris and Eleni E Magira and Dimitri S. Monos},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={165 6},
  pages={788-94}
}
Chronic beryllium disease (CBD) is a hypersensitivity granulomatosis characterized by beryllium hypersensitivity (BH) and mediated by CD4+ T cells. However, all individuals with BH may not develop CBD. To examine the role of the three different human leukocyte antigen (HLA) Class II isotypes in BH with (CBD) and without clinical disease (BHWCD), we performed DNA-based typing of HLA-DPB1, HLA-DQB1, and HLA-DRB1 loci on 55 subjects with BH (25 with established CBD and 30 with BHWCD), and compared… CONTINUE READING

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