Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury

@article{Monshi2013HumanLA,
  title={Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury},
  author={Manal M Monshi and Lee Faulkner and Andrew Gibson and Rosalind E. Jenkins and John Farrell and Caroline J. Earnshaw and Ana Alfirevic and Karin Cederbrant and Ann K. Daly and Neil S French and Munir Pirmohamed and B. Kevin Park and Dean J. Naisbitt},
  journal={Hepatology},
  year={2013},
  volume={57}
}
The role of the adaptive immune system in adverse drug reactions that target the liver has not been defined. For flucloxacillin, a delay in the reaction onset and identification of human leukocyte antigen (HLA)‐B*57:01 as a susceptibility factor are indicative of an immune pathogenesis. Thus, we characterize flucloxacillin‐responsive CD4+ and CD8+ T cells from patients with liver injury and show that naive CD45RA+CD8+ T cells from volunteers expressing HLA‐B*57:01 are activated with… Expand
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