Human leukaemic stem cells: a novel target of therapy.

  title={Human leukaemic stem cells: a novel target of therapy.},
  author={Wolfgang R Sperr and Alexander W. Hauswirth and Stefan Ioan Florian and Leopold Ohler and Klaus Geissler and Peter Valent},
  journal={European journal of clinical investigation},
  volume={34 Suppl 2},
Acute myeloid leukaemia (AML) is a life-threatening haematopoietic disease that is characterized by clonal growth and the accumulation of myelopoietic progenitor cells. Although AML cells only have a limited potential to undergo differentiation and maturation, each AML clone is organized in a hierarchical manner similar to normal haematopoiesis. Recent data have shown that each AML clone consists of leukaemic stem cells and their progeny, and that AML stem cells differ from more mature cells in… CONTINUE READING

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