Human leptin stimulates systemic nitric oxide production in the rat.


OBJECTIVE Apart from having an effect on energy balance, leptin is also involved in cardiovascular regulation and in the pathogenesis of obesity-associated hypertension. We investigated the effect of leptin on nitric oxide (NO) production. RESEARCH METHODS AND PROCEDURES Wistar rats were placed in metabolic cages, and urine was collected in 2-hour periods… (More)


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