Human leptin: from an adipocyte hormone to an endocrine mediator.

  title={Human leptin: from an adipocyte hormone to an endocrine mediator.},
  author={Machteld Wauters and Robert Vincent Considine and Luc F. Van Gaal},
  journal={European journal of endocrinology},
  volume={143 3},
Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the research following this discovery focused on the role of leptin in body weight regulation, aiming to illuminate the pathophysiology of human obesity. However, more and more data are emerging that leptin is not only important in the regulation of food intake and energy balance, but that it also has a function as a metabolic and neuroendocrine hormone. It is now clear that it is especially involved in… CONTINUE READING


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A preliminary meta-analysis of the association of LEPR polymorphisms with anthropometric variables

  • M Heo, RL Leibel, BB Boyer, WK Chung, M Koulu, M Karvonen
  • Obesity Research
  • 1999

Associations between leptin receptor gene polymorphisms and obesity-related phenotypes in obese women

  • M Wauters, I Mertens, LV Gaal, C. Bouchard
  • International Journal of Obesity
  • 1999

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