Human large granular lymphocytes and natural killing ultrastructural studies of strontium-induced degranulation.

@article{Neighbour1982HumanLG,
  title={Human large granular lymphocytes and natural killing ultrastructural studies of strontium-induced degranulation.},
  author={P. Andrew Neighbour and Harris S. Huberman and Y. Y. Kress Kress},
  journal={European journal of immunology},
  year={1982},
  volume={12 7},
  pages={
          588-95
        }
}
Large granular lymphocytes (LGL) are a subpopulation of human peripheral blood mononuclear cells believed to contain the mediators of spontaneous cytotoxicity or natural killing. In the present study, the mononuclear cells were enriched for LGL by differential density centrifugation on Percoll gradients and examined by transmission electron microscopy. The ultrastructure of LGL and of their binding interaction with natural killer-susceptible target cells (K562) is described in detail. Some… CONTINUE READING
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