Human langerhans cells are more efficient than CD14(-)CD1c(+) dermal dendritic cells at priming naive CD4(+) T cells.

@article{Furio2010HumanLC,
  title={Human langerhans cells are more efficient than CD14(-)CD1c(+) dermal dendritic cells at priming naive CD4(+) T cells.},
  author={Laetitia Furio and Isabelle Briotet and Alexandra Journeaux and Hermine Billard and Josette P{\'e}guet-Navarro},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 5},
  pages={1345-54}
}
Few data are available regarding the role of human skin dendritic cells (DCs) in driving T-cell responses. In this study we analyzed the relative capacity of Langerhans cells (LCs) and dermal CD14(-)CD1c(+) DCs (DDCs) to trigger naive CD4(+) T-cell proliferation and differentiation. DC subsets were purified after a 2-day migration from epidermis and dermis of the same skin sample. Migratory LCs showed far more activated phenotype than CD1c(+)DDCs and distinct expression of new molecules of the… CONTINUE READING

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