Human lamin B contains a farnesylated cysteine residue.

@article{Farnsworth1989HumanLB,
  title={Human lamin B contains a farnesylated cysteine residue.},
  author={Clyde Farnsworth and Sharon L Wolda and Michael H Gelb and John A. Glomset},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 34},
  pages={20422-9}
}
We recently showed that HeLa cell lamin B is modified by a mevalonic acid derivative. Here we identified the modified amino acid, determined its mode of linkage to the mevalonic acid derivative, and established the derivative's structure. A cysteine residue is modified because experiments with lamin B that had been biosynthetically labeled with [3H]mevalonic acid or [35S]cysteine and then extensively digested with proteases yielded 3H- or 35S-labeled products that co-chromatographed in five… CONTINUE READING

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