Human lamin B contains a farnesylated cysteine residue.

  title={Human lamin B contains a farnesylated cysteine residue.},
  author={Clyde Farnsworth and Sharon L Wolda and Michael H Gelb and John A. Glomset},
  journal={The Journal of biological chemistry},
  volume={264 34},
We recently showed that HeLa cell lamin B is modified by a mevalonic acid derivative. Here we identified the modified amino acid, determined its mode of linkage to the mevalonic acid derivative, and established the derivative's structure. A cysteine residue is modified because experiments with lamin B that had been biosynthetically labeled with [3H]mevalonic acid or [35S]cysteine and then extensively digested with proteases yielded 3H- or 35S-labeled products that co-chromatographed in five… CONTINUE READING


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  • M. W. Kirschner
  • Biochem .
  • 1977

Handbook of Analytical Deriuatization ReBiol

  • M. H. Schaffer, G. R. Stark
  • Proc. Natl. Acad. Sci. U. S. A
  • 1976

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