Human lactoferrin stimulates skin keratinocyte function and wound re‐epithelialization

@article{Tang2010HumanLS,
  title={Human lactoferrin stimulates skin keratinocyte function and wound re‐epithelialization},
  author={L. G. Tang and J.-J. Wu and Qianli Ma and T. Cui and Fotios M. Andreopoulos and Joel Gil and Jose Valdes and Stephen C. Davis and J-f Li},
  journal={British Journal of Dermatology},
  year={2010},
  volume={163}
}
  • L. Tang, J. Wu, +6 authors J. Li
  • Published 1 July 2010
  • Biology, Medicine
  • British Journal of Dermatology
Background  Human lactoferrin (hLF), a member of the transferrin family, is known for its antimicrobial and anti‐inflammatory effects. Recent studies on various nonskin cell lines indicate that hLF may have a stimulatory effect on cell proliferation. 
Promoting effect of lactoferrin on barrier function and epithelial differentiation of human keratinocytes.
TLDR
The findings suggest that bovine lactoferrin promotes epithelial differentiation by a p38-MAPK-dependent mechanism.
Multifunctional capacity and therapeutic potential of lactoferrin.
TLDR
According to this review, LF is a good immunomodulatory agent that acts on both innate and adaptive immune responses and possesses antimicrobial activity against parasites, fungi, and viruses and also has regenerative properties at tissue level and anti-carcinogenic activity.
Effects of Lactoferrin on Skin Wound Healing
The skin wound healing is a complex biological process that requires the regulation of different cell types. Lactoferrin is a metal-binding glycoprotein secreted from glandular epithelial cells and
The promising pro-healing role of the association of mesoglycan and lactoferrin on skin lesions.
TLDR
It is shown that human keratinocytes, fibroblasts and endothelial cells migrate and invade more rapidly when treated with the mesoglycan/lactoferrin association, and the use of the association strongly promote cell activation underlying the correct tissue regeneration.
Roles of lactoferrin on skin wound healing.
  • Y. Takayama, R. Aoki
  • Medicine, Biology
    Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2012
TLDR
In an in vitro model of wound contraction, lactoferrin promoted fibroblast-mediated collagen gel contraction and indicates that lact oferrin supports multiple biological processes involved in wound healing.
Lactoferrin: an alternative view of its role in human biological fluids.
TLDR
It is argued that the current literature supports a microbiostatic role, but not a microbicidal role, for hLF in vivo, and the literature also supports a role for hF in inhibiting colonization and infection of epithelial surfaces by microorganisms and in protecting tissues from neutrophil-mediated damage.
Lactoferrin as a regenerative agent: the old-new panacea?
TLDR
This review collected and analyzed the data on the regenerative effects of Lf, as well as paid specific attention to their molecular basis.
Transdermal administration of lactoferrin with sophorolipid.
TLDR
Results indicate the feasibility of the transdermal administration of bLf with Sophorolipid, and suggest a significant synergism between bLF and SL.
Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota
TLDR
In diabetic mouse wounds, LFcinB treatment led to the eradication of Bacillus pumilus, a decrease in Staphylococcus aureus, and an increase in the Staphyllococcus xylosus prevalence, suggesting a downregulation of inflammation in diabetic wounds.
Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts.
TLDR
It is suggested that LRP1 expressed in human epidermal keratinocytes and dermal fibroblasts contributes to AMP-IBP5-mediated cell migration and proliferation, supporting its crucial role in cutaneous wound healing process.
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References

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Regulation of epidermal Langerhans cell migration by lactoferrin
TLDR
The results suggest that as a constituent of normal skin, LF may play a role in homeostatic regulation of cutaneous immune function and the possession by LF of direct immunomodulatory and/or anti‐inflammatory activity, probably associated in this case with inhibition of cytokine production.
Lactoferrin--a novel bone growth factor.
TLDR
It is concluded that lactoferrin may have a physiological role in bone growth and healing, and a potential therapeutic role as an anabolic factor in osteoporosis.
Human lactoferrin: a novel therapeutic with broad spectrum potential
  • E. Weinberg
  • Biology, Medicine
    The Journal of pharmacy and pharmacology
  • 2001
TLDR
The recombinant form of human Lf has become available and development of the product for use in a wide range of medical conditions can now be anticipated.
Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo.
TLDR
Lactoferrin has powerful anabolic, differentiating, and antiapoptotic effects on osteoblasts and inhibits osteoclastogenesis and is a potential therapeutic target in bone disorders such as osteoporosis and is possibly an important physiological regulator of bone growth.
Effects of lactoferrin and its peptides on proliferation of rat intestinal epithelial cell line, IEC-18, in the presence of epidermal growth factor.
TLDR
Results indicate that LF induces cell proliferation by a mechanism distinct from that of TF, and a synergistic effect of LF and EGF was observed in both cell proliferation and DNA synthesis assays.
Effect of lactoferrin on the growth of a human colon adenocarcinoma cell line-comparison with transferrin
TLDR
In the presence of low-concentration iron solutions, lactoferrin stimulated the cell growth, and the effect was more pronounced with the ferric chloride solution.
Lactoferrin interaction with retinoid signaling: cell growth and apoptosis in mammary cells.
TLDR
It is proposed that nuclear lactoferrin interacts with retinoic acid signaling pathways in cells and alters/blocks the signals so that cells remain in the cell cycle and/or do not enter the apoptotic pathway.
Lactoferrin potently inhibits osteoblast apoptosis, via an LRP1-independent pathway
TLDR
It is demonstrated that lactoferrin promotes osteoblast survival, an effect that may contribute to its anabolic skeletal actions in vivo and suggest that the molecular mechanisms that underpin the ability of lact oferrin to promote cell survival differ fundamentally from those which subserve its mitogenic actions.
Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells.
TLDR
Observations that endocytosis of Lf is inhibited by the HB-19 pseudopeptide, and the lack of L f endocybosis in proteoglycan-deficient cells despite Lf binding, point out that both nucleolin and proteoglycans are implicated in the mechanism of LF endocyTosis.
Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin.
TLDR
It is shown that apoptotic human cell lines of diverse lineages synthesize and secrete lactoferrin, a pleiotropic glycoprotein with known antiinflammatory properties, and it is demonstrated that lact oferrin selectively inhibited migration of granulocytes but not mononuclear phagocytes, both in vitro and in vivo.
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