Human kidneys play an important role in the elimination of propofol.

@article{Takizawa2005HumanKP,
  title={Human kidneys play an important role in the elimination of propofol.},
  author={Daisuke Takizawa and Haruhiko Hiraoka and Fukuyo Goto and Koujirou Yamamoto and Ryuya Horiuchi},
  journal={Anesthesiology},
  year={2005},
  volume={102 2},
  pages={
          327-30
        }
}
BACKGROUND Extrahepatic clearance of propofol has been suggested because its total body clearance exceeds hepatic blood flow. However, it remains uncertain which organs are involved in the extrahepatic clearance of propofol. In vitro studies suggest that the kidneys contribute to the clearance of this drug. The purpose of this study was to confirm whether human kidneys participate in propofol disposition in vivo. METHODS Ten patients scheduled to undergo nephrectomy were enrolled in this… CONTINUE READING

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