Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide.

@article{Dubourg2001HumanKT,
  title={Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide.},
  author={Laurence Dubourg and Christian Michoudet and Pierre Cochat and Gabriel Baverel},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 8},
  pages={1615-23}
}
The nephrotoxic effects of the antineoplastic drug ifosfamide have been attributed to its hepatic metabolite chloroacetaldehyde. The effects of chloroacetaldehyde on isolated human kidney cortex tubules metabolizing lactate (a physiologic substrate in human kidneys) were investigated. At concentrations of > or =0.5 mM, chloroacetaldehyde was toxic to the human kidney tubules, as demonstrated by a dramatic decrease in cellular ATP levels and a large increase in lactate dehydrogenase release… CONTINUE READING