Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment.

@article{Jang2013HumanKP,
  title={Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment.},
  author={Kyung-Jin Jang and Ali Poyan Mehr and Geraldine A. Hamilton and L. A. McPartlin and Seyoon Chung and K. Y. Suh and Donald E. Ingber},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2013},
  volume={5 9},
  pages={
          1119-29
        }
}
Kidney toxicity is one of the most frequent adverse events reported during drug development. The lack of accurate predictive cell culture models and the unreliability of animal studies have created a need for better approaches to recapitulate kidney function in vitro. Here, we describe a microfluidic device lined by living human kidney epithelial cells exposed to fluidic flow that mimics key functions of the human kidney proximal tubule. Primary kidney epithelial cells isolated from human… CONTINUE READING

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