Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma.

@article{Han2005HumanKI,
  title={Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma.},
  author={Won Kyo Han and Anwar Alinani and Chin-lee Wu and Dror M. Michaelson and Massimo F. Loda and Francis J. McGovern and Ravi I. Thadhani and Joseph V. Bonventre},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 4},
  pages={1126-34}
}
Human kidney injury molecule-1 (hKIM-1) is a type 1 transmembrane protein that is not detectable in normal kidney tissue but is expressed at high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury. Therefore, it was hypothesized that renal tumors express hKIM-1 and release this protein into the urine. Forty renal cell carcinoma (RCC) and 484 nonrenal tumors were analyzed by immunohistochemistry for expression of hKIM-1 (group… CONTINUE READING

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