Human keratocyte migration into collagen gels declines with in vitro ageing

@article{Sandeman2000HumanKM,
  title={Human keratocyte migration into collagen gels declines with in vitro ageing},
  author={Susan Sandeman and Marcus C. Allen and Christopher Liu and Richard G A Faragher and Andrew W. Lloyd},
  journal={Mechanisms of Ageing and Development},
  year={2000},
  volume={119},
  pages={149-157}
}
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22 Citations
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22 Citations

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The Transfer of Ocular Cells Using Collagen
TLDR
The results show that the cell seeding number must be critically balanced with the concentration of gel for it to be used as transplant material.
Insulin growth factor promotes human corneal fibroblast network formation in vitro.
TLDR
In conclusion, IGF signaling and the MEK-1/2 pathway are involved in the cell network formation of corneal fibroblast cells from aged donors.
Online monitoring of the mechanical behavior of collagen hydrogels: influence of corneal fibroblasts on elastic modulus.
TLDR
The ability to examine the mechanical properties of cell-seeded constructs in response to the culture environments--in particular, the response tothe addition of drugs or chemical reagents--which will provide a useful tool in studying the mechano-feedback loop between cells and their surrounding matrix is demonstrated.
Up-regulation of semaphorin 3A in human corneal fibroblasts by epidermal growth factor released from cocultured human corneal epithelial cells.
Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model
TLDR
It is shown that senescence induces extensive phenotypic changes in hMSCs and abrogates their protective activity in a murine model of LPS‐induced lethal endotoxemia and provides candidate gene signatures which may be useful to evaluate the therapeutic potential of h MSCs used in future clinical studies.
Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts.
Aberrant heterodimerization of keratin 16 with keratin 6A in HaCaT keratinocytes results in diminished cellular migration
Cyclin D1 Overexpression Permits the Reproducible Detection of Senescent Human Vascular Smooth Muscle Cells
TLDR
Quantitative cytochemical analysis of senescent and growing vascular smooth muscle cells indicates that cyclin D1 reactivity is a considerably better marker of replicative senescence than senescENCE‐associated β‐galactosidase activity.
Electric signals regulated immunomodulation and wound healing
TLDR
It is proposed that the EF-induced re-distribution of the receptors on the cell surface results in a shift of membrane receptors between the cathode-facing and the anodes-facing membrane of the cell, which would help to overcome the threshold of signal transduction at the higher density receptor side.
Cellular senescence, ageing and disease
TLDR
Recent findings which suggest that cellular senescence does contribute to ageing and the development/progression of disease are discussed.
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References

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