Human keratocyte migration into collagen gels declines with in vitro ageing

@article{Sandeman2000HumanKM,
  title={Human keratocyte migration into collagen gels declines with in vitro ageing},
  author={Susan Sandeman and Marcus C. Allen and Christopher Liu and R G A Faragher and Andrew W. Lloyd},
  journal={Mechanisms of Ageing and Development},
  year={2000},
  volume={119},
  pages={149-157}
}
Although senescence in various cell types has been shown to have detrimental effects on wound repair, the effect of this phenomenon on corneal function with increasing age has yet to be elucidated. This study investigated the effect of in vitro ageing on keratocyte migration into a collagen gel matrix. The keratocyte cell strain EK1. BR was cultured to late passage and a comparison of early passage migration with that of late passage migration was carried out. Early or late passage keratocytes… 

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