Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.

@article{DeCastro1996HumanKE,
  title={Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.},
  author={Rosana DeCastro and Ying Zhang and Hong-fen Guo and Hiroaki Kataoka and M. K. Gordon and Bryan P. Toole and Gopa Roy Biswas},
  journal={The Journal of investigative dermatology},
  year={1996},
  volume={106 6},
  pages={1260-5}
}
Increased levels of matrix metalloproteinases are associated with tissue degradation and remodeling during tumor invasion and wound healing. In both processes, there is evidence that cell interactions between fibroblasts and tumor cells or keratinocytes lead to increases in metalloproteinase production. We have previously isolated and purified a tumor cell surface protein, EMMPRIN (extracellular matrix metalloproteinase inducer), which stimulates production of interstitial collagenase… CONTINUE READING
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